In a recent study published by Mandotori, D. 2021; Vitamin K2 has a dual role in Bone Loss and Vascular Calcification. Vitamin K2 deficiency is proving to be responsible for the "calcium paradox" phenomenon, characterized by low calcium deposition in the bone.
Looking back to a study published by Refitt, D.M. 2003; Orthosilicic acid stimulates collagen synthesis and osteoblastic differentiation. Gene expression of alkaline phosphatase and osteocalcin increased significantly following treatment. Silicon deficiency in animals leads to bone defects and plays an important role in bone metabolism, bone remolding and repair.
According to a study by Sato, T 2020; Vitamin K2 (MK-7) concluded that MK-7 has a higher efficacy due to its higher bioavailability and longer half-life than another other vitamin K source. MK-7 increases bone mineral density and promotes bone quality and strength.
The study by Zhou, H. 2019; concluded that Orthosilicic Acid "Accelerates Bone Formation" in Osteoblast-like cells through P13K-AKt-MTOR pathways. Numerous animal experiments have shown that an appropriate increase in the intake of silicon is beneficial to enhancing bone density.