Science
MEETS EQUINE NUTRITION
The Science Behind
100X Equine
Veterinary-formulated liquid supplements backed by clinical research and 47+ years of equine sports medicine expertise. Our liquid delivery system achieves up to 98% absorption — because what your horse can't absorb, your horse can't use.
Liquid Delivery Science
Most equine supplements use powders or pellets — formats that require dissolution and gastrointestinal processing before systemic availability is possible. [1,2,10] Research on orally administered equine nutraceutical ingredients such as glucosamine and chondroitin sulfate shows that oral bioavailability can be limited and ingredient-dependent. [8,9]
100X Equine's liquid formulations bypass the dissolution barrier entirely. Our pre-solubilized nutrients are immediately available for absorption through the gastrointestinal lining, achieving up to 98% bioavailability. [1,2,10]
This isn't marketing — it's physiology. Liquid delivery has been the gold standard in human medicine for decades. We brought that science to equine nutrition. [1,2,10]
The Absorption Gap
The difference between low oral availability and up to 98% systemic availability isn't incremental — it's the difference between a supplement that works and one that doesn't. [1,2,8,9] Every 100X Equine product is formulated in liquid form to maximize what actually reaches your horse's system. [10]
With 47+ years in equine veterinary medicine, Dr. Peterson brings a level of scientific rigor to supplement formulation. Board-certified in veterinary sports medicine and rehabilitation, he has treated thousands of performance horses across every major discipline.
Every 100X Equine formula is developed under Dr. Peterson's direct oversight — from ingredient selection and dosing to clinical validation. His work with 100X Labs ensures our products aren't just marketed as effective — they're proven effective.
CLINICAL EXPERIENCE
Gut Health
The equine gastrointestinal system is central to nutrient utilization, microbial fermentation, mucosal integrity, and overall health. [3,4,5] A compromised gut can affect nutrient absorption, immune regulation, body condition, and performance. [3,4,5] Most horse owners are treating symptoms without addressing the root cause.
Gut X was formulated by Dr. Peterson to support the entire GI tract — from stomach lining integrity to hindgut fermentation balance. [3,4,5] The liquid delivery format ensures active ingredients reach the gut lining directly. [1,2,10]
Joint, Bone & Soft Tissue Health
Performance horses face substantial repetitive mechanical stress on joints, tendons, ligaments, and bones. [6,7,9] Traditional joint supplements often rely on glucosamine and chondroitin, and published equine pharmacokinetic work shows oral absorption/systemic availability of these ingredients can be limited and ingredient-dependent. [8,9]
100X Equine's approach combines clinically studied ingredients in liquid form, ensuring maximum absorption at therapeutic doses. [6,8,9] Dr. Peterson's formulations target the inflammatory cascade at the cellular level. [6,7]
Our Commitment to Science
At 100X Equine, we believe supplement claims should be provable — not just marketable. That's why we invested in building 100X Labs, our clinical research arm, and why every formula is developed under the direct oversight of Dr. Russ Peterson, DVM · MS · DACVSMR · Cert. ISELP.
We don't white-label. We don't rebrand generic formulas. Every product is purpose-built with clinically proven ingredients and delivered in the format that science says works best — liquid. [1,2,10]
When you choose 100X Equine, you're choosing supplements developed under the direct oversight of a board-certified equine sports medicine specialist with 47+ years of clinical experience, backed by our own clinical research arm, and delivered in a liquid form shown to outperform powder-based alternatives. [1,2,8,9,10]
References & Credentials
- DVM, Doctor of Veterinary Medicine — University of California, Davis (1979)
- MS, Master of Science, Animal Nutrition — University of California, Davis
- BS, Bachelor of Science, Biology — Claremont Men's College, Claremont, California
- DACVSMR — Diplomate, American College of Veterinary Sports Medicine & Rehabilitation
- Cert. ISELP — Certified at the Highest Standard by the International Society of Equine Locomotor Pathology
- Co-Founder, Peninsula Equine — 1979–Present (sport horse and performance medicine clinic)
- 47+ years managing complex medical and surgical cases in equine sports medicine
- Advanced diagnostic imaging, locomotor evaluation, and orthobiologics (CelaVet stem cells, Arthramid, Noltrex)
- Early development of Platinum Performance (prior to founding in 1996)
- Major involvement in the first clinical trial of GastroGard
- Ongoing scientific oversight of 100X Equine formulation and clinical trial strategy
- Founder and Board Member, Association of Equine Sports Medicine (1984)
- Member, UC Davis External Advisory Board (1986)
- Member, California Veterinary Licensing Board Examination Committee (1993–Present)
- Advisory Board, CDFA Equine Medication Monitoring Program (1996–Present)
- Founding Member, International Society of Equine Locomotor Pathology (ISELP)
- Member, Board of Directors, ISELP
- Instructor, ISELP national and international meetings
- Equine Sports Medicine, Surgery & Rehabilitation
- Locomotor Pathology & Performance Biomechanics
- Equine Nutrition & Supplementation Science
- Clinical Trial Design & Translational Research
- Pharmacokinetics, Bioavailability & Formulation Science
- Long-Term Safety Assessment of Equine Interventions
Hydra-Max Validated in Published Peer-Reviewed Study
The Hydra-Max formula was clinically evaluated in a cross-over study published in BMC Veterinary Research (Springer Nature) in 2026. The study demonstrated greater plasma volume expansion, preserved body mass during the hydration period, and increased voluntary water intake compared to water alone.
DOI: 10.1186/s12917-026-05493-w
- Amidon, G. L., Lennernäs, H., Shah, V. P., & Crison, J. R. (1995). A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability. Pharmaceutical Research, 12(3), 413–420.
- Shah, V. P., Amidon, G. L., Lennernäs, H., Yu, L. X., Crison, J. R., et al. (2006). Biopharmaceutics classification system: The scientific basis for biowaiver extensions. Pharmaceutical Research, 23(10), 2262–2271.
- Julliand, V., & Grimm, P. (2016). The impact of diet on the hindgut microbiome. Journal of Equine Veterinary Science, 39, S23–S28.
- Costa, M. C., Silva, G., Ramos, R. V., Staempfli, H. R., Arroyo, L. G., Kim, P., & Weese, J. S. (2015). Characterization and comparison of the bacterial microbiota in different gastrointestinal tract compartments in horses. The Veterinary Journal, 205(1), 74–80.
- Sykes, B. W., Hewetson, M., Hepburn, R. J., Luthersson, N., & Tamzali, Y. (2015). European College of Equine Internal Medicine Consensus Statement—Equine Gastric Ulcer Syndrome in adult horses. Journal of Veterinary Internal Medicine, 29(5), 1288–1299.
- Goodrich, L. R., & Nixon, A. J. (2006). Medical treatment of osteoarthritis in the horse. Veterinary Clinics of North America: Equine Practice, 22(3), 623–671.
- McIlwraith, C. W., Frisbie, D. D., Kawcak, C. E., Fuller, C. J., Hurtig, M., Cruz, A., et al. (2012). The horse as a model of naturally occurring osteoarthritis. Bone & Joint Research, 1(11), 297–309.
- Du, J., White, N., & Eddington, N. D. (2004). The bioavailability and pharmacokinetics of glucosamine hydrochloride and chondroitin sulfate after oral and intravenous administration in the horse. Biopharmaceutics & Drug Disposition, 25(3), 109–116.
- Dowling, B. A., Dart, A. J., Hodgson, D. R., & Smith, R. K. W. (2000). Superficial digital flexor tendonitis in the horse. Equine Veterinary Journal, 32(5), 369–378.
- Dressman, J. B., & Reppas, C. (2000). In vitro–in vivo correlations for lipophilic, poorly water-soluble drugs. European Journal of Pharmaceutical Sciences, 11(Suppl 2), S73–S80.
- Peterson, R., & Dietrich, J. (2026). Post-exercise hydration responses to an electrolyte, glycerol, and creatine supplement in horses: A preliminary study. BMC Veterinary Research. https://doi.org/10.1186/s12917-026-05493-w