The Science of 100X Equine

Veterinary-formulated liquid supplements, backed by clinical research and 47+ years of equine sports-medicine expertise.

Every Equine supplement label makes a promise. But a horse is built to ferment fiber, not to absorb a concentrated supplement and what your horse can't absorb, your horse can't use. So the number on the scoop is the wrong thing to measure.

The right question... the one every horse owner should be asking is simply: how effective is it, really?

That's what the science below answers.

Liquid Delivery Science

Most equine supplements use powders or pellets, formats that require dissolution and gastrointestinal processing before systemic availability is possible. [1,2,10] Research on orally administered equine nutraceutical ingredients such as glucosamine and chondroitin sulfate shows that oral bioavailability can be limited and ingredient-dependent. [8,9]

100X Equine's liquid formulations help bypass the dissolution barrier almost entirely. Our pre-solubilized nutrients are immediately available for absorption through the gastrointestinal lining, achieving up to 98% available for absorption. [1,2,10]

This isn't marketing... it's physiology. Liquid delivery has been the gold standard in human medicine for decades.

We brought that science to equine nutrition. [1,2,10]

Gut Health

The equine gastrointestinal system is central to nutrient utilization, microbial fermentation, mucosal integrity, and overall health. [3,4,5] A compromised gut can affect nutrient absorption, immune regulation, body condition, and performance. [3,4,5] Most horse owners are treating symptoms without addressing the root cause.

Gut X was formulated by Dr. Peterson to support the entire GI tract — from stomach lining integrity to hindgut fermentation balance. [3,4,5] The liquid delivery format ensures active ingredients reach the gut lining directly. [1,2,10]

Our Commitment to Science

At 100X Equine, we believe supplement claims should be provable - not just marketable. That's why we invested in building 100X Labs, our clinical research arm, and why every formula is developed under the direct oversight of Dr. Russ Peterson, DVM · MS · DACVSMR · Cert. ISELP.

We don't white-label. We don't rebrand generic formulas. Every product is purpose-built with clinically studied ingredients and delivered in the format that science says works best - liquid. [1,2,10]

When you choose 100X Equine, you're choosing supplements developed under the direct oversight of a board-certified equine sports medicine specialist with 47+ years of clinical experience, backed by our own clinical research arm, and delivered in a liquid form shown to outperform powder-based alternatives. [1,2,8,9,10]

Published Scientific References

1. Amidon, G. L., Lennernäs, H., Shah, V. P., & Crison, J. R. (1995). A theoretical basis for a biopharmaceutic drug classification: The correlation of in vitro drug product dissolution and in vivo bioavailability. Pharmaceutical Research, 12(3), 413–420.

2. Shah, V. P., Amidon, G. L., Lennernäs, H., Yu, L. X., Crison, J. R., et al. (2006). Biopharmaceutics classification system: The scientific basis for biowaiver extensions. Pharmaceutical Research, 23(10), 2262–2271.

3. Julliand, V., & Grimm, P. (2016). The impact of diet on the hindgut microbiome. Journal of Equine Veterinary Science, 39, S23–S28.

4. Costa, M. C., Silva, G., Ramos, R. V., Staempfli, H. R., Arroyo, L. G., Kim, P., & Weese, J. S. (2015). Characterization and comparison of the bacterial microbiota in different gastrointestinal tract compartments in horses. The Veterinary Journal, 205(1), 74–80.

5. Sykes, B. W., Hewetson, M., Hepburn, R. J., Luthersson, N., & Tamzali, Y. (2015). European College of Equine Internal Medicine Consensus Statement—Equine Gastric Ulcer Syndrome in adult horses. Journal of Veterinary Internal Medicine, 29(5), 1288–1299.

6. Goodrich, L. R., & Nixon, A. J. (2006). Medical treatment of osteoarthritis in the horse. Veterinary Clinics of North America: Equine Practice, 22(3), 623–671.

7. McIlwraith, C. W., Frisbie, D. D., Kawcak, C. E., Fuller, C. J., Hurtig, M., Cruz, A., et al. (2012). The horse as a model of naturally occurring osteoarthritis. Bone & Joint Research, 1(11), 297–309.

8. Du, J., White, N., & Eddington, N. D. (2004). The bioavailability and pharmacokinetics of glucosamine hydrochloride and chondroitin sulfate after oral and intravenous administration in the horse. Biopharmaceutics & Drug Disposition, 25(3), 109–116.

9. Dowling, B. A., Dart, A. J., Hodgson, D. R., & Smith, R. K. W. (2000). Superficial digital flexor tendonitis in the horse. Equine Veterinary Journal, 32(5), 369–378.

10. Dressman, J. B., & Reppas, C. (2000). In vitro–in vivo correlations for lipophilic, poorly water-soluble drugs. European Journal of Pharmaceutical Sciences, 11(Suppl 2), S73–S80.

11. Peterson, R., & Dietrich, J. (2026). Post-exercise hydration responses to an electrolyte, glycerol, and creatine supplement in horses: A preliminary study. BMC Veterinary Research. https://doi.org/10.1186/s12917-026-05493-w