Gut & Immune
Gut X
Liquid gut health and immune support, the foundation every other protocol builds on.
$134.79
Gut X · Every horse, every day
Common Questions
One pump per dose, top-dressed on feed. Load for the first 14 days with 2 pumps a day, then settle into a once-daily maintenance pump. The included calibrated pump makes every dose exact. No scooping, no guesswork.
Gut X is a palatable liquid that coats the existing ration, so most horses accept it with no fuss. If yours is especially fussy, our equine nutritionists help you transition, included free with every order.
Anytime. Manage everything in your account or by SMS: pause, change delivery dates, or cancel with no fees and no phone tree.
Enroll once and keep a qualifying subscription active: after acceptance and a 30-day qualifying period, the $20,000 Colic Surgery Coverage Program reimburses up to $20,000 in eligible colic-surgery costs while coverage stays active. One-time orders aren’t covered.
Yes. USEF and FEI compliant. No prohibited substances, so it’s cleared for horses showing under both rule sets.
Many horse owners notice visible changes within 7–14 days, especially in body condition, appetite, manure quality, weight, and coat shine. Gut X is not a short-term protocol. It is designed to be fed daily as long-term gut and nutritional support.
Gut X supplies targeted gut-support ingredients, including beta glucan and hyaluronic acid, in the functional form and amount used in Gut X. Daily feeding helps support digestive function, gut lining health, nutrient use, body condition, and overall wellness over time.
And if you don’t see the difference, you’re backed by our 90-day money-back guarantee.
Gut X · Liquid-First Delivery
Nutrition starts in the gut.
Liquid delivery makes it work.
Digestive ComfortImmune SupportBody Condition Support
Gut X is delivered in a proprietary liquid form with up to 99% availability1, 2. Powders & pellets must first break apart, hydrate, & disperse into usable surface area inside a moving gut, a slow, variable process that leaves availability as low as 2.5%3.
Gut X arrives dispersed, at the correct particle size, suspended and ready on contact, so the gut isn’t left to solve dispersion problems it was never designed to solve.
1Goodridge et al. (2011). doi.org/10.1038/nature100712Balogh et al. (2008). doi.org/10.1021/jf80170293Du et al. (2004). doi.org/10.1002/bdd.392
Free shipping
90-day money-back
Pause or cancel anytime
Your 2 Gallon Subscription includes
- ✓2 Gallons of Gut X + 2 pumps
- ✓Free ½ gallon of Gut X ($89.95 value) *New Subscription Offer Only
- ✓$20,000 Colic Surgery Coverage Program
Every discipline. Every level. Real horses on Dr. Peterson’s Protocol.
4.9
★★★★★
out of 5
Based on 16,004 verified reviews
Real Gut X Stories
Real Horses. Real Change.
The owners who watched it happen, in their own words.
Rev · Off-track Thoroughbred · 30 days
Rev came in ulcer-prone and struggling to hold weight. Thirty days on one pump of Gut X a day, and coat bloom and condition are the visible signs of a gut that’s finally absorbing what it’s fed.
Day 0
Day 0. Off-track and ulcer-prone, struggling to hold weight.
Day 30
Day 30. One pump a day. Topline and condition back.
Daniela’s mare · ~3 months
Through the summer she carried visible ribs and a dropped topline. A few months on Gut X and the weight (and the energy) came back, for around $30 a month.
Before
Before. Ribs and hip showing, topline flat.
After
After. Weight back on, coat bright, more energy.
Emily’s mare · Day 1 → Day 30
Shot as a 30-day challenge: same horse, same spot, a month apart. One pump of Gut X a day, and the topline and condition started coming up.
Day 1
Day 1. Starting point: flat topline, dull bloom.
Day 30
Day 30. Topline filling, coat coming up.
The absorption gap
What your horse can’t absorb,
your horse can’t use.
Most supplements are powders or pellets. They have to dissolve and survive the gut before any of it counts, and most of it never does. Gut X is liquid and pre-dispersed, so it’s ready the moment it reaches the gut wall.
Liquid Gut X
vs
99%
up to 99% availability
Powders & pellets
2.5%
absorption as low as 2.5%1
Oral bioavailability of administered actives. Powder/pellet figure per Du et al. (2004)1; cited in full above.
With most supplements, you pay for a full dose and your horse absorbs a fraction of it. You’re not getting what you think you’re paying for. With Gut X, what’s on the label is what reaches your horse.
Hyaluronan
Works on contact. Coats and soothes the gut lining the moment it arrives, with no breakdown step to lose along the way.
β-glucan
Binds the gut’s immune receptors directly, supporting a healthy immune response from where it lands.
The physiology
It’s not marketing. Liquid delivery has been the standard in human medicine for decades. Gut X brings it to the barn.
Liquid vs. the rest
Why form is the whole game.
The active ingredients aren’t the differentiator, delivery is. Here’s how liquid stacks up against the dry supplements in most feed rooms.
Gut X · Liquid
Powders
Pellets
Availability
Up to 99%1,2
3–30%3
3–15%4
Goes to work
On contact
Must dissolve first
Needs to break down first
Dose accuracy
One pump, exact
Scoop & settle
Eats around it
Picky-eater approved
Yes
Hit or miss
Hit or miss
Colic coverage
$20,000
It depends
It depends
References
1Goodridge et al. (2011). doi.org/10.1038/nature10071
2Balogh et al. (2008). doi.org/10.1021/jf8017029
3Du et al. (2004). doi.org/10.1002/bdd.392
4Raval et al. (2025). doi.org/10.2174/0124681873309964240521074809
Ingredients
What’s in the jug, why it’s there, and what the science says.
Every active ingredient in Gut X is at the upper end of its peer-reviewed efficacy range5, 6, 9, 10. No undisclosed dosing. Every gram is named, sourced, and dosed for clinical effect.
The system
Liquid SystemProprietary liquid carrier
The proprietary carrier stabilizes, suspends, and pre-disperses every active before feeding, supporting uniform dosing and up to 99%2, 7, 8 availability, while powders and pellets can assimilate as low as 2.5%1.
up to
99%
availability
Beta Glucanβ-1,3 / 1,6 glucan
β-1,3 / 1,6 glucan, a soluble fiber that works on contact with the gut’s immune tissue, supporting a healthy stomach lining and immune response.2, 4, 10
196
mg / oz
Hyaluronic AcidSodium hyaluronate
A high molecular weight form of hyaluronic acid that works on contact, helping form a hydrated, protective coating across the stomach and small intestine.7, 8, 10, 11
200
mg / oz
References
- 1Du, J., White, N., & Eddington, N. D. (2004). Bioavailability of glucosamine and chondroitin sulfate in horses. Biopharmaceutics & Drug Disposition, 25(3), 109–116. doi.org/10.1002/bdd.392
- 2Goodridge, H. S., et al. (2011). Dectin-1 activation through beta-glucan immune receptor signaling. Nature, 472, 471–475. doi.org/10.1038/nature10071
- 3Goodridge, H. S., et al. (2009). β-glucan recognition by the innate immune system. Immunological Reviews, 230, 38–50. doi.org/10.1111/j.1600-065X.2009.00793.x
- 4Tsoni, S. V., & Brown, G. D. (2008). β-glucans and Dectin-1 immune receptor signaling. Annals of the New York Academy of Sciences, 1143, 45–60. doi.org/10.1196/annals.1443.019
- 5Picetti, et al. (2021). Oral β-glucan and complement activity in horses. Veterinary World, 14(4), 835–840. doi.org/10.14202/vetworld.2021.835-840
- 6Lacerenza, et al. (2024). β-glucan supplementation and LPS-induced endotoxemia in horses. Animals, 14(3), 474. doi.org/10.3390/ani14030474
- 7Balogh, L., et al. (2008). Absorption and tissue affinity of high-molecular-weight hyaluronan after oral administration. Journal of Agricultural and Food Chemistry, 56(22), 10582–10593. doi.org/10.1021/jf8017029
- 8Sammarco, et al. (2019). Hyaluronan and intestinal mucosal healing. Cells, 8(9), 1074. doi.org/10.3390/cells8091074
- 9Slovis, N. M. (2017). Polysaccharide treatment reduces gastric ulceration in active horses. Journal of Equine Veterinary Science, 50, 116–120. doi.org/10.1016/j.jevs.2016.11.011
- 10Andrews, et al. (2025). Hyaluronan + β-glucan and gastric ulcer scores in horses. Equine Veterinary Education, 1–10. doi.org/10.1111/eve.70009
- 11Misra, S., et al. (2015). Interactions between hyaluronan and its receptors (CD44, RHAMM) regulate inflammation. Frontiers in Immunology, 6, 201. doi.org/10.3389/fimmu.2015.00201
The Protocol
Dr. Peterson’s two-phase protocol
Load for the first 14 days with 2 pumps a day, then settle into a once-daily maintenance pump. Two pumps a day is also recommended for stressful situations, like travel, weather changes, pasture mate changes, and show preparation.
Day 0Day 14Ongoing
≈ 3-month supply per gallon
≈ 4-month supply per gallon
From the barn
112,000 horses. Here are a few of them.
Real members, real horses, real results. Tag #100XEquine to be featured.
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4
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4
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Chief Veterinary Officer
47 years of Equine Medicine, in one jug.
The Veterinary Standard Behind 100X Equine
Dr. Russ Peterson, DVM, MS, DACVSMR, Cert. ISELP brings nearly five decades of equine medicine, sport horse performance, rehabilitation, nutrition, and clinical decision-making to 100X Equine.
As Chief Veterinary Officer, Dr. Peterson helps guide the clinical thinking behind every 100X Equine formula, from ingredient selection to dosing strategy to how those actives are delivered inside the horse.
Gut X reflects that standard: clinically studied beta glucan and hyaluronic acid, transparent dosing, and a proprietary liquid carrier designed to keep the actives stable, dispersed, and ready for biological contact.
Board-certifiedSports Medicine & RehabilitationEquine NutritionFormulation Science
The $20,000 promise
How the Colic Surgery Coverage works.
Colic surgery can run $5,000–$20,000+. An enrolled, qualifying subscription backs your horse with up to $20,000 in surgical reimbursement, so the worst day isn’t also a financial one.
01
Enroll & subscribe
Complete the enrollment form and keep a qualifying Gut X subscription active. Once accepted, your horse is in the 100X Colic Surgery Coverage Program, subject to eligibility conditions and a 30-day qualifying period.
02
Stay covered
Coverage stays active as long as your subscription does. Keep feeding 2 ounces daily for gut support, keep the protection in place.
03
Up to $20,000 reimbursed
If your horse needs colic surgery while enrolled, the program reimburses eligible surgical costs up to $20,000.
$20,000Max reimbursement / horse
$0Added cost, included with subscription
30 daysQualifying period after acceptance
Colic Surgery Coverage is a reimbursement program, not insurance, and is not a health claim. Eligibility, waiting periods, and terms apply; coverage applies only while a subscription remains active. See full program terms.
$20,000 Colic Surgery Coverage
Enroll once with a qualifying subscription and the program reimburses up to $20,000 in colic-surgery costs while coverage stays active.
90-Day Money-Back Guarantee
Feed it daily for 90 days. If you don’t see the difference, we refund you, with free shipping on every order.
Subscribe & Save
Put any protocol on auto-delivery and lock in a better price on every order. Pause, skip, swap, or change your delivery dates anytime, fully in your control.
Still deciding
Questions, answered.
Many owners notice changes within 7–14 days in body condition, appetite, manure quality, and coat shine. Gut X is daily, long-term support, not a quick fix. If you don’t see the difference, you’re backed by our 90-day money-back guarantee.
Gut X is a palatable liquid that coats the existing ration, so most horses accept it with no fuss. If yours is especially fussy, our equine nutritionists help you transition, included free with every order.
Your Gut X subscription is fully flexible. Manage it anytime in your account or by SMS: pause, change delivery dates, or cancel with no fees and no phone tree.
Enroll once and keep a qualifying subscription active: after acceptance and a 30-day qualifying period, the $20,000 Colic Surgery Coverage Program reimburses up to $20,000 in eligible colic-surgery costs while coverage stays active. One-time orders aren’t covered.
The full system
Pair Gut X with another protocol.
Stack more and save up to 40% off. Adjust anytime.
Joint, Soft Tissue & Bone
Osteo-MAX
Bone density, joint integrity, and recovery for hard-working and aging horses.
$231.56
Mobility
Joint Flex Plus
Everyday joint flexibility and comfort for performance and senior horses.
$134.79
Topline & Muscle
Amino-MAX
Amino acids for topline, muscle, and a stronger frame under saddle.
$176.94
Electrolytes + Creatine
Hydra-MAX
Electrolyte and hydration support for sweat, travel, and hot, hard days.
$117.56
Calm & Focus
Max Calm
Liquid calming support for focus and rideability, without the dullness.
$134.79
Put your horse on the protocol.
Start with Gut X. Activate up to $20,000 in colic surgery coverage. Built on Dr. Peterson’s 47+ years of equine medicine.
Start with Gut XEnrollment in the 100X Colic Surgery Coverage Program is required to activate coverage.
See program terms.
Gut X
★★★★★4.916,004 reviews112,000+ horses
Liquid gut and immune support. The foundation every other protocol builds on.
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- Gastric supportCoats and soothes the stomach lining.
- Body conditionBetter absorption for weight and topline.
- Colic supportUp to $20,000 in colic surgery coverage.
Beta glucanHyaluronanLiquid Delivery
Free shipping
90-day money-back
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Product details
Every active is at the upper end of its peer-reviewed efficacy range. No proprietary blends hiding a dose.
See the full labelThe systemLiquid SystemProprietary liquid carrier99%availability
The proprietary carrier stabilizes, suspends and pre-disperses every active before feeding, supporting uniform dosing and up to 99%1,2,3 availability, while powders and pellets can assimilate as low as 2.5%4.
Beta Glucanβ-1,3 / 1,6 glucan196mg / oz
β-1,3 / 1,6 glucan, a soluble fiber that works on contact with the gut’s immune tissue, supporting a healthy stomach lining and immune response.1,5,6
Hyaluronic AcidSodium hyaluronate200mg / oz
A high molecular weight form of hyaluronic acid that works on contact, helping form a hydrated, protective coating across the stomach and small intestine.2,3,6,7
References
1Goodridge et al. (2011). 10.1038/nature10071
2Balogh et al. (2008). 10.1021/jf8017029
3Sammarco et al. (2019). 10.3390/cells8091074
4Du et al. (2004). 10.1002/bdd.392
5Tsoni & Brown (2008). 10.1196/annals.1443.019
6Andrews et al. (2025). 10.1111/eve.70009
7Misra et al. (2015). 10.3389/fimmu.2015.00201
8Goodridge et al. (2009). 10.1111/j.1600-065X.2009.00793.x
9Picetti et al. (2021). 10.14202/vetworld.2021.835-840
10Lacerenza et al. (2024). 10.3390/ani14030474
11Slovis (2017). 10.1016/j.jevs.2016.11.011
Load with 2 pumps a day for the first 14 days, then settle into 1 pump a day.
- Pump it straight over the existing ration. The liquid coats the feed, so picky eaters take it without a fight.
- One gallon is 128 maintenance doses, up to a 4 month supply for one horse.
- The loading phase runs about 30 days per gallon.
Most owners notice manure quality, appetite and coat changes in the first week. Gut lining support keeps compounding, with full benefit typically by month 6.
- Day 1 to 14, the loading dose is doing the work.
- Day 14 onward, one pump a day holds it.
- This is daily long-term gut and immune support, not a quick fix.
The comparison
Why form is the whole game.
The actives are not the differentiator, delivery is. Here is how liquid stacks up against the dry supplements in most feed rooms.
Gut X liquidPowder / pellet
Delivery form
Pre-dispersed liquid, suspendedDry particles, must hydrate
Availability
Up to 99%1,2As low as 2.5%3
Dose accuracy
One pump, exactScoop, settles and separates
Goes to work
On contactMust break down first
Dose consistency
196 mg beta glucan + 200 mg HA, every pumpVaries with settling
References1 Goodridge et al. (2011). 10.1038/nature10071
2 Balogh et al. (2008). 10.1021/jf8017029
3 Du et al. (2004). 10.1002/bdd.392
2 Balogh et al. (2008). 10.1021/jf8017029
3 Du et al. (2004). 10.1002/bdd.392
Why liquid
Ready the moment it hits the gut.
Gut X is delivered in a proprietary liquid form with up to 99% availability1,2. Powders and pellets must first break apart, hydrate and disperse into usable surface area inside a moving gut, a slow, variable process that leaves availability as low as 2.5%3.
1Goodridge et al. (2011)2Balogh et al. (2008)3Du et al. (2004)
Colic Surgery Coverage
Up to $20,000 toward colic surgery.
Included at no extra cost with an enrolled, qualifying subscription. Not insurance you buy, a benefit you keep while you stay on protocol.
01
Enroll & subscribe
Complete the enrollment form and keep a qualifying subscription active. Once accepted, a 30-day qualifying period applies before reimbursement eligibility begins.
02
Stay on protocol
Coverage stays active as long as the subscription does. Pause it and coverage pauses with it.
03
If the worst happens
Submit the surgical invoice and we reimburse up to $20,000 of the cost.
$20,000Maximum lifetime reimbursement per covered horse
$0Additional cost on any subscription
Program terms, eligibility and exclusions apply. One-time orders are not covered. Read the full terms
Who formulates it
Dr. Russ Peterson, DVM
MS · DACVSMR · Cert. ISELP
Chief Veterinary Officer
Chief Veterinary Officer
Nearly five decades of equine medicine, sport horse performance, rehabilitation and nutrition. Gut X reflects that standard: clinically studied beta glucan and hyaluronic acid, transparent dosing, and a liquid carrier built to keep the actives stable and dispersed.
Start the protocol
One pump a day. Feed it for 90 days, and if your horse is not doing better, we refund you.
Subscribe & SaveFree shipping. Pause, change or cancel anytime.