Most owners report a change in movement, comfort, and willingness to work within the first 30 days, and some sooner. Bone remodels on a longer clock than soft tissue, which is why the loading phase runs 30 to 60 days for bone support.
Osteo-MAX supplies structural nutrients that hay and grain do not provide in this form or amount: silicon as orthosilicic acid, hyaluronic acid, vitamin K2 and D3, and the amino acids collagen is built from. Fed daily, they support bone formation, joint lubrication, and connective tissue repair over time.
And if you don’t see the difference, you’re backed by our 90-day money-back guarantee.
Strong bones. Sound joints.
One pump a day.
Bone SupportJoint ComfortTendon & Ligament Support
Bone, joint, and connective tissue work as one system. Osteo-MAX supports all three in one daily ounce, top-dressed over the feed you already give.
Each ounce carries silicon as orthosilicic acid, hyaluronic acid, vitamins K2 and D3, and a 6,975 mg amino acid blend, delivered in a proprietary liquid form with up to 99% availability1, 2. Powders & pellets must first break apart, hydrate, & disperse inside a moving gut, which leaves availability as low as 2.5%3.
- ✓1 Gallon of Osteo-MAX + 1 pump
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8,518 verified reviews from working barns.
Every discipline. Every level. Real horses on Dr. Peterson’s Protocol.
This is what doing well looks like.
Denim, 90 days apart. Same horse, one pump a day.
Shot in March at the start of the protocol and again in June. One pump of Osteo-MAX a day through the spring.
Day 0. March, the day the protocol started.
Day 90. June, 90 days on one pump a day.
What your horse can’t absorb,
your horse can’t use.
Most joint and bone supplements are powders or pellets. They have to dissolve and survive the gut before any of it counts, and most of it never does. Osteo-MAX is liquid and pre-dispersed, so it’s ready the moment it reaches the gut wall.
Oral bioavailability of administered actives. Powder/pellet figure per Du et al. (2004)1; cited in full above.
With most supplements, you pay for a full dose and your horse absorbs a fraction of it. You’re not getting what you think you’re paying for. With Osteo-MAX, what’s on the label is what reaches your horse.
The bioavailable form of silicon. Already in solution, so it arrives in the form the bone-building cells can actually use.
High molecular weight, pre-hydrated. No breakdown step to lose it in, which matters for a molecule this large.
It’s not marketing. Liquid delivery has been the standard in human medicine for decades. Osteo-MAX brings it to the barn.
Why form is the whole game.
The actives aren’t the differentiator, delivery is. Here’s how liquid stacks up against the pelleted and powdered joint supplements in most feed rooms.
What’s in the jug, why it’s there, and what the science says.
One pump is one ounce. Every active below is listed at its amount in that ounce, with the published research it rests on. The amino acid blend is proprietary, listed at its 6,975 mg total.
Liquid SystemProprietary liquid carrier
A pre-dispersed liquid suspension designed to support serving consistency and reduce the dry-form disintegration step.1, 2
Amino Acid BlendGlycine, lysine, phenylalanine, ornithine, arginine, proline, threonine, serine
Supplies amino acids used in collagen and whole-body protein synthesis, including building blocks found throughout tendon, ligament, and connective tissue.3–8
Siliconas Orthosilicic Acid
Orthosilicic acid is a bioavailable form of silicon. Published work links it to type I collagen synthesis, osteoblast differentiation, bone-formation markers, and regulation of osteoclast activity.9–13
Hyaluronic AcidHyaluronan
Hyaluronan is a normal component of synovial fluid and extracellular matrix. Oral HA has absorption, tissue-distribution, and clinical literature, including direct equine research.14–17
Vitamin K2 (MK7)Menaquinone-7
Supports activation of vitamin K-dependent proteins such as osteocalcin and matrix Gla protein, which are involved in bone mineralization and regulation of soft-tissue calcification.18–22
BiotinVitamin B7
Biotin has direct equine evidence for supporting hoof horn quality. Because new hoof horn must grow out, visible changes are expected over months, not days.23–26
Vitamin D3Cholecalciferol
Supports calcium and phosphorus homeostasis and normal bone metabolism. Total intake from the complete ration should be considered.27–29
- 1Goodridge, H. S., Reyes, C. N., Becker, C. A., et al. (2011). Activation of the innate immune receptor Dectin-1 upon formation of a phagocytic synapse. Nature, 472, 471–475. doi.org/10.1038/nature10071
- 2Balogh, L., Polyak, A., Mathe, D., et al. (2008). Absorption, uptake and tissue affinity of high-molecular-weight hyaluronan after oral administration in rats and dogs. Journal of Agricultural and Food Chemistry, 56(22), 10582–10593. doi.org/10.1021/jf8017029
- 3Graham-Thiers, P. M., & Kronfeld, D. S. (2005). Amino acid supplementation improves muscle mass in aged and young horses. Journal of Animal Science, 83(12), 2783–2788. academic.oup.com
- 4Van den Hoven, R., Bauer, A., Hackl, S., et al. (2011). Changes in potential markers of muscle-cell degradation in exercised horses supplemented with a protein and amino acid mixture. Journal of Animal Physiology and Animal Nutrition. doi.org/10.1111/j.1439-0396.2010.01097.x
- 5Tanner, S. L., Wagner, A. L., Digianantonio, R. N., et al. (2014). Dietary crude protein intake influences rates of whole-body protein synthesis in weanling horses. The Veterinary Journal. sciencedirect.com
- 6Latham, C. M., Wagner, A. L., et al. (2019). Effects of dietary amino acid supplementation on measures of whole-body and muscle protein metabolism in aged horses. Journal of Animal Physiology and Animal Nutrition. doi.org/10.1111/jpn.12992
- 7Mastellar, S. L., Coleman, R. J., & Urschel, K. L. (2016). Controlled trial of whole body protein synthesis and plasma amino acid concentrations in yearling horses fed graded amounts of lysine. The Veterinary Journal. sciencedirect.com
- 8Mastellar, S. L., Moffet, A., Harris, P. A., & Urschel, K. L. (2016). Effects of threonine supplementation on whole-body protein synthesis and plasma metabolites in growing and mature horses. The Veterinary Journal. sciencedirect.com
- 9Pritchard, A. (2020). The role alterations in dietary calcium and silicon balance play on bone and cartilage in horses and poultry. Graduate thesis. proquest.com
- 10Nielsen, B. D. (2023). A review of three decades of research dedicated to making equine bones stronger: implications for horses and humans. Animals, 13(5), 789. doi.org/10.3390/ani13050789
- 11Logan, A. A., & Nielsen, B. D. (2021). Training young horses: the science behind the benefits. Animals, 11(2), 463. doi.org/10.3390/ani11020463
- 12Fowler, A. L., Pyles, M. B., Hayes, S. H., et al. (2022). Effect of weight change on markers of bone turnover and phosphorus excretion. Journal of Equine Veterinary Science. sciencedirect.com
- 13Saastamoinen, M., & Valtonen, S. S. E. (2020). The effect of diet composition on the digestibility and fecal excretion of phosphorus in horses: a potential risk of phosphorus leaching? Animals. go.gale.com
- 14Carmona, J. U., Argüelles, D., Deulofeu, R., et al. (2009). Effect of the administration of an oral hyaluronan formulation on clinical and biochemical parameters in young horses with osteochondrosis. Veterinary and Comparative Orthopaedics and Traumatology. doi.org/10.3415/VCOT-09-01-0001
- 15Niemelä, T. M., Tulamo, R. M., Aaltonen, K., et al. (2018). Changes in biomarkers in equine synovial fluid two weeks after intra-articular hyaluronan treatment: a randomised double-blind clinical trial. BMC Veterinary Research. doi.org/10.1186/s12917-018-1512-2
- 16Niemelä, T. M., Tulamo, R. M., Carmona, J. U., et al. (2019). Evaluation of the effect of experimentally induced cartilage defect and intra-articular hyaluronan on synovial fluid biomarkers in intercarpal joints of horses. Acta Veterinaria Scandinavica. doi.org/10.1186/s13028-019-0460-6
- 17da Silva Xavier, A. A., da Rosa, P. P., et al. (2021). An assessment of the effectiveness of hyaluronic acid and polyacrylamide hydrogel in horses with osteoarthritis: systematic review and network meta-analysis. Research in Veterinary Science. sciencedirect.com
- 18National Research Council. (2007). Nutrient Requirements of Horses, 6th revised edition. National Academies Press. doi.org/10.17226/11653
- 19Mandatori, D., Pelusi, L., Schiavone, V., et al. (2021). The dual role of vitamin K2 in bone-vascular crosstalk: opposite effects on bone loss and vascular calcification. Nutrients, 13(4), 1222. doi.org/10.3390/nu13041222
- 20Atkins, G. J., Welldon, K. J., Wijenayaka, A. R., et al. (2009). Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by gamma-carboxylation-dependent and independent mechanisms. American Journal of Physiology-Cell Physiology. doi.org/10.1152/ajpcell.00216.2009
- 21Yilmaz, I. C., Güler, T., Ekmen, E. G., & Özçelik, M. (2026). The effects of boron mineral on performance, bone and mineral metabolism in Purebred Arabian foals. Biological Trace Element Research. doi.org/10.1007/s12011-026-05138-x
- 22Vervuert, I., & Stratton-Phelps, M. (2021). The safety and efficacy in horses of certain nutraceuticals that claim to have health benefits. Veterinary Clinics of North America: Equine Practice. vetequine.theclinics.com
- 23Geyer, H., & Schulze, J. (1994). The long-term influence of biotin supplementation on hoof horn quality in horses. Schweizer Archiv für Tierheilkunde, 136, 137–149.
- 24Josseck, H., Zenker, W., & Geyer, H. (1995). Hoof horn abnormalities in Lipizzaner horses and the effect of dietary biotin on macroscopic aspects of hoof horn quality. Equine Veterinary Journal, 27(3), 175–182. doi.org/10.1111/j.2042-3306.1995.tb03060.x
- 25Zenker, W., Josseck, H., & Geyer, H. (1995). Histological and physical assessment of poor hoof horn quality in Lipizzaner horses and a therapeutic trial with biotin and a placebo. Equine Veterinary Journal, 27(3), 183–191. doi.org/10.1111/j.2042-3306.1995.tb03061.x
- 26Burns, T. A. (2021). Feeding the foot: nutritional influences on equine hoof health. Veterinary Clinics of North America: Equine Practice. vetequine.theclinics.com
- 27Dittmer, K. E., & Thompson, K. G. (2011). Vitamin D metabolism and rickets in domestic animals: a review. Veterinary Pathology, 48(2), 389–407. doi.org/10.1177/0300985810375240
- 28Robles, M., Hammer, C., Staniar, W. B., et al. (2021). Nutrition of broodmares. Veterinary Clinics of North America: Equine Practice. vetequine.theclinics.com
- 29Robles, M., Gautier, C., Mendoza, L., et al. (2017). Maternal nutrition during pregnancy affects testicular and bone development, glucose metabolism and response to overnutrition in weaned horses up to two years. PLoS ONE, 12(1), e0169295. doi.org/10.1371/journal.pone.0169295
Dr. Peterson’s two-phase protocol
Load with 2 pumps a day: 30 days for soft tissue, 30 to 60 days for bone. Then settle into a once-daily maintenance pump. Two pumps a day is also recommended through heavy work, rehab, and show season.
84,000 horses. Here are a few of them.
Real members, real horses, real results. Tag #100XEquine to be featured.
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47 years of Equine Medicine, in one jug.
The Veterinary Standard Behind 100X Equine
Dr. Russ Peterson, DVM, MS, DACVSMR, Cert. ISELP brings nearly five decades of equine medicine, sport horse performance, rehabilitation, nutrition, and clinical decision-making to 100X Equine.
As Chief Veterinary Officer, Dr. Peterson helps guide the clinical thinking behind every 100X Equine formula, from ingredient selection to dosing strategy to how those actives are delivered inside the horse.
Osteo-MAX reflects that standard: silicon as orthosilicic acid, hyaluronic acid, vitamins K2 and D3, and a 6,975 mg amino acid blend, all named on the panel and delivered in a proprietary liquid carrier built to keep them stable and ready for biological contact.
Three structures. One movement system.
Bone, joints, tendons, and ligaments work together as one movement system. Many supplement programs address them separately. Osteo-MAX brings their nutritional support together in one daily ounce.
Bone
Orthosilicic acid, vitamin K2, and vitamin D3 support the collagen framework of bone, normal mineral metabolism, and ongoing bone remodeling.
Joint
Hyaluronan is a natural component of synovial fluid and extracellular matrix. Osteo-MAX supplies 150 mg already in solution to support normal joint lubrication and function.
Tendon & ligament
A 6,975 mg amino acid blend supplies glycine, lysine, proline, and other amino acids used in collagen and protein synthesis, supporting normal maintenance and turnover of tendons, ligaments, fascia, and other connective tissues. Orthosilicic acid supports that same collagen synthesis.
Additional structural support Also supplies biotin to support hoof horn quality. Amounts are per one-ounce pump, as listed on the current Product Facts panel. See the full panel.
Show-Safe Formula
No prohibited substances. Osteo-MAX is USEF and FEI compliant, so it stays legal for horses competing under both rule sets.
90-Day Money-Back Guarantee
Feed it daily for 90 days. If you don’t see the difference, we refund you, with free shipping on every order.
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